| Abstract: |
A Learning Health System (LHS) is an essential paradigm for addressing the evolving complexities of healthcare systems, fostering continuous improvement, adaptability, and stakeholder collaboration. By integrating knowledge management with technological advancements, LHS enhances data-driven decision-making and the responsiveness of healthcare interventions. Artificial Intelligence (AI) has emerged as a powerful tool within Learning Health Systems, yet its evolving nature presents challenges related to ethical, traceable, and trustworthy data management. Distributed Ledger Technology (DLT) offers immutable and transparent data governance, yet its full potential remains unrealized due to the absence of integrated frameworks that could reinforce accountability and reliability in AI-driven processes. Addressing this gap is critical for developing robust, ethical, and efficient healthcare solutions. This paper examines the synergistic potential of AI and DLT within LHS, proposing a framework that leverages systematic knowledge integration, predictive analytics, and proactive interventions. By harnessing AI-driven automation, IoT-enabled data collection, and the secure, decentralized architecture of DLT, LHS can advance evidence-based healthcare, mitigate disparities, and promote equitable access to high-quality care. |